Explain how bone marrow analysis helps establish an AML diagnosis
What will be an ideal response?
Answer: The first step in bone marrow analysis is to establish the overall cellularity of the bone marrow. Next, the number of erythroblasts are counted and expressed as a percentage of the total number of nucleated cells in the marrow. A cutoff of 50% is considered standard. If erythroblasts comprise <50% of all nucleated cells, the nonerythroid precursors (i.e., myeloblasts and monoblasts) are then counted. If erythroblasts comprise >50% of all nucleated cells, a diagnosis of acute erythroleukemia (AEL) is suspected. If myeloblasts and/or monoblasts are >20% of the total count, AML is strongly suspected.
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Why are aromatase inhibitors used in postmenopausal women to reduce estrogen levels? (hint: What is the source of estrogen in women with nonfunctioning or surgically removed ovaries?)
What will be an ideal response?
Hospitals in which of the following categories have medical students, interns, and residents treating patients under the supervision of licensed physicians?
A) General or community B) Research C) Teaching D) Specialty