What were the complications associated with the first membrane oxygenator developed by Clowes and associates in 1956? I. leukocytopenia II. coagulopathy III. renal dysfunction IV. hemolysis

A. II, IV only
B. I, II, III only
C. I, III, IV only
D. II, III, IV only

ANS: D
A. Incorrect response: See explanation D.
B. Incorrect response: See explanation D.
C. Incorrect response: See explanation D.
D. Correct response: The first membrane oxygenator was developed by Clowes and associates in 1956. However, this membrane oxygenator could not support life for more than a few hours. Common complications then were (1) thrombocytopenia, (2) coagulopathy, (3) hemolysis, and (4) renal and pulmonary dysfunction.

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