While researching the drug amiodarone, you read that the drug is considered to be highly protein bound upon entering the body. Knowing this, you can deduce that:
a. The drug is largely ineffective when administered by intravenous route
b. The drugs half-life will be relatively short due to the rapid elimination of the free, or unbound, percentage
c. Much of the drug remains active in the bloodstream and only a small percentage is bound in tissues
d. The drug remains bound to proteins but will slowly release the active component when necessary resulting in a long half-life
d
Rationale: a. When administered in therapeutic dosages, intravenous routes provides the most rapid, effective dose.
b. The drug will have a long half-life as the bound component will slowly release as the free or unbound active component is metabolized.
c. When the drug is highly protein bound, much of the drug will be stored in protein reservoirs. Only a small amount remains in the bloodstream as an active metabolite.
d. Correct.
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