A patient presents with polyuria and extreme thirst and is given exogenous ADH. For which of the following conditions would this treatment be effective?
a. Neurogenic diabetes insipidus
b. Psychogenic diabetes insipidus
c. Nephrogenic diabetes insipidus
d. SIADH
ANS: A
Neurogenic diabetes insipidus is caused by the insufficient secretion of ADH; thus, exogenous ADH would be useful in the treatment of this disorder. Psychogenic diabetes insipidus is due to increased intake of water and would not respond to exogenous ADH. ADH is high in nephro-genic diabetes insipidus; thus, exogenous ADH would be contraindicated. SIADH is manifested by high levels of ADH; thus, exogenous administration of ADH would be contraindicated.
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