Which of the following therapies actually lyses the clot rather than prevents future clots?
a. Aspirin
b. Heparin
c. TPA
d. Coumadin
ANS: C
TPA is normally released from endothelial cells and activates plasminogen, which then gradually lyses the fibrin clot. TPA is used therapeutically to lyse pathologic clots in thrombotic disease. Aspirin inhibits platelet function, heparin binds to antithrombin to inhibit thrombin, and Coumadin interferes with normal synthesis of the vitamin K–dependent proteins.
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