Aspirin-induced bleeding and Willebrand disease (VWD), type 1, are detected reliably by:
a. Bleeding time
b. Point-of-care testing (POCT)
c. PFA 100 Platelet Function Analyzer
d. Nephelometry
ANS: C
The PFA 100 Platelet Function Analyzer assesses platelet dysfunction. Aspirin and VWD both negatively affect platelet function, although by entirely different mechanisms. Aspirin acetylates cyclooxygenase, thus preventing the eventual production of thromboxane A2, an important platelet agonist. In type 1 VWD, von Willebrand factor (VWF) is decreased and therefore platelet adhesion is abnormal. The bleeding time is not a reliable test for platelet function, although it can be abnormal (prolonged).
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