Which of the following causes hypoxic stimulation of the carotid bodies? 1. Large decrease in arterial PO2 2. Large decrease in O2 content 3. CO poisoning

a. 1 only
b. 1 and 2 only
c. 1, 2, and 3
d. 1 and 3 only

ANS: A
When the PaO2 is low carotid body sensitivity to a given [H+] increases; in this way hypoxemia increases ventilation for any given pH.

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