What etiologic factor is associated with the onset of nocturnal asthma?
a. Aspiration of gastric acid at night
b. Supine position
c. Variation in acetylcholine secretion at night
d. Variation in the secretion of insulin at night
ANS: A
It probably is due to the known physiologic decrease in the airway tone during sleep, which has been attributed to variation in catecholamine and cortisol secretion. Aspiration of gastric acid also may play a role in some patients with increased symptoms at night.
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