A patient has 30% Hb F. Which of the following can be eliminated?
a. Four missing genes for a chain production
b. Heterozygous hereditary persistence of Hb F
c. Thalassemia intermedia
d. The patient is a normal 1-month-old infant
ANS: A
a Chains are required for Hb F synthesis; therefore if all four genes for a chain synthesis are missing, then no Hb F can be produced. Thirty percent Hb F can be seen in all the other situations listed.
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