Aspirin acts ______________ not ______________

Fill in the blank(s) with correct word

peripherially; centrally: Aspirin acts primarily peripherally at the site where the pain originates (e.g., pain produced at a tooth) but also has some central activity in the CNS. During the pain response at the tooth site, bradykinin (a substance that is a vasodilator and stimulates nerve endings of pain fibers) is released from the injured tissue which stimulates pain receptors in the area.