Mary, a 7-year-old, was admitted to the hospital after experiencing severe anemia following a respiratory infection. Her father has a history of RBC membrane abnormality and recently underwent a splenectomy to help alleviate the problem
Upon examination, it was revealed that Mary had hepatosplenomegaly and slight bruising on her forearms. A CBC was ordered, with the following results:
HGB 9.0 g/dL
HCT 24%
WBC 11 × 109/L
RBC 3.8 × 1012/L
MCV 102 fl
MCH 25 pg
MCHC 40%
PLT 275 × 109/L
Peripheral smear: moderate macrocytes and stomatocytes
Which of the following is most consistent with a presumptive diagnosis in this case?
a. PNH
b. HS
c. DHS
d. HE
Correct Answer: B
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