The principal mediator of an allergic reaction is:

a. Hymenoptera
b. Injected penicillin
c. Delayed hypersensitivity
d. Histamine

d
Rationale: a. Hymenoptera is a classification of insects that includes wasps and bees.
b. Injected penicillin is the most common cause of anaphylactic reactions.
c. Delayed hypersensitivity is a type of allergic reaction that results in skin rash.
d. Correct.

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