Name the genetic mutation that induces increased concentration of prothrombin in the circulation that leads to increased risk of venous thrombosis

a. G ? A substitution on nucleotide 20210 of the prothrombin gene
b. Lysine to glutamic acid substitution on the sixth position on the beta globin chain
c. Arginine to glutamine substitution at the 506 position of prothrombin
d. Translocation of chromosome 22 onto the long arm of chromosome 9

Correct Answer: A