Which of the following is the mechanism of action of proton pump inhibitors?
a. noncompetitively inhibits the proton pump in the membrane of the parietal cells
b. neutralizes acid in the membrane of the parietal cells
c. reduces histamine-stimulated gastric acid secretion
d. improves gastric emptying
a. PPIs suppress acid by irreversibly inhibiting the proton pump in the membrane of the parietal cells. This pump is the final common pathway for acid secretion. Thus, PPIs achieve nearly total suppression of acid secretion. To restore acid secretion again, it is necessary to either synthesize new pumps or activate resting pumps, which takes about 3 to 5 days.
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What are the small bones that make up the wrist called?
A) Metacarpals B) Carpals C) Metatarsals D) Tarsals
A laboratory professional is reviewing a peripheral blood smear of a 10-year-old patient and notes that 35% blasts are present. Which of the following diagnoses is likely based on these findings?
a. Myelodysplastic syndrome b. Acute leukemia c. Chronic myeloid leukemia d. Aplastic anemia