Malignant proliferation of plasma cells with osteolytic bone lesions and the presence of monoclonal immunoglobulin in the serum describe:
a. Waldenström macroglobulinemia
b. Marginal zone B-cell lymphoma
c. Follicle center lymphoma
d. Plasma cell myeloma
ANS: D
Plasma cell myeloma is characterized by a monoclonal proliferation of malignant plasma cells. A monoclonal spike is usually observed after serum protein electrophoresis. Patients often have osteolytic bone lesions.
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