What conclusion was drawn regarding the use of permissive hypercapnia as a lung protective strategy for limiting VILI in patients with ALI?
A. The data were inconclusive.
B. Permissive hypercapnia worked best with patients who were ventilated with VTs around 6 ml/kg.
C. Permissive hypercapnia significantly reduced the mortality rate in patients ventilated with VTs of 12 ml/kg.
D. The data did not detect any difference between permissive hypercapnia, and ALI patients receiving conventional or high-VT ventilation in limiting VILI.
?ANS: C
A. Incorrect response: See explanation C.
B. Incorrect response: See explanation C.
C. Correct response: Data suggest that hypercapnic acidosis may have a protective effect against VILI on ALI patients receiving conventional or high tidal volume ventilation. Permissive hypercapnia is an acceptable consequence of lung-protective ventilation. Experimental data have also provided evidence that hypercapnic acidosis has favorable anti-inflammatory properties.
D. Incorrect response: See explanation C.
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