Which of the following is most often linked to cumulative toxicity?

A) ethyl alcohol
B) methyldopa
C) aspirin
D) caffeine

A) ethyl alcohol
Ethyl alcohol is most often linked to cumulative toxicity, out of the answer choices. This may occur rapidly. A cumulative effect occurs when the body is not able to metabolize and excrete one dose of a drug completely before the next dose is given. With repeated doses, the drug starts to collect in the blood and body tissues.