Which of the following is the most specific indicator of accelerated intravascular red cell destruction?
a. Increased serum bilirubin
b. Increased haptoglobin
c. Decreased hematocrit
d. Decreased haptoglobin
ANS: D
When red cells are destroyed in the circulation, hemoglobin is released into plasma. Haptoglobin binds the free hemoglobin and thus decreases in plasma. This is specific for intravascular hemolysis.
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