Which of the following drugs should not be given together with lovastatin (Mevacor)?

a. penicillin
b. clarithromycin
c. metronidazole
d. ibuprofen

b. Clarithromycin (Biaxin) interacts with statin drugs. Clarithromycin, erythromycin, and ketoconazole inhibit the P450 cytochrome enzyme that metabolizes lovastatin, resulting in increased levels.