What evidence is there that genes are involved in Alzheimer's disease (AD)?

What will be an ideal response?

While the incidence of AD increases with age, there are those who develop AD in their 40s or 50s. This "early-onset" AD appears to have a genetic basis. This form of the disease is usually of rapid onset and course. While early-onset AD appears to run in families, numerous genes have been implicated. Mutations on many different chromosomes have been identified as playing a potential causal role. Genes that code for products that play a role in the development plaques and tangles have been identified. While much has been discovered about this disease, there are many questions that remain unanswered. GRADING RUBRIC - 8 points total, 4 points each for discussing two different pieces of evidence.