Which of the following is a feature of type II congenital dyserythropoietic anemia type II (CDA II)?
a. Giant, multinucleated red cell precursors
b. Microcytic red cells
c. Positive sucrose hemolysis test
d. Negative acidified serum test (Ham test)
ANS: A
CDA II is also known as hereditary erythroblastic multinuclearity with positive acidified serum (HEMPAS). It is the most common type of CDA, and is, as the alternate name suggests, associated with giant, multinucleated erythroblastic precursors. The acidified serum test (Ham test) is positive, not the sucrose hemolysis test. Red cells are usually normocytic, although often anisocytosis is noted.
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