Sublingual or buccal administered drugs must initially be able to go through the
a. epithelium of the oral mucosa (tongue or buccal mucosa).
b. connective tissue of the GI tract.
c. tissues of the stomach.
d. tissues of the nasopharynx.
a. Sublingually or buccally administered drugs must be able to go through the epithelium of the oral mucosa (tongue or buccal mucosa) before they can enter the blood and be distributed to the site of action. This barrier is referred to as the tissue/blood barrier.
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