Which drug interaction occurs when a patient takes both acetaminophen and codeine? 

A. The effect of both drugs is increased, causing a beneficial effect.
B. The effect of both drugs is decreased, or one drug cancels out the other.
C. The effect of both drugs is increased, causing a toxic effect.
D. The effect of the acetaminophen is decreased by the codeine.
E. The effect of the codeine is decreased by the acetaminophen.

A. The effect of both drugs is increased, causing a beneficial effect.
Combining acetaminophen and codeine increases the activity of both drugs, allowing the physician to prescribe a lower dose of each.

Health Professions

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