Patients who are heterozygous for Hb Lepore have a clinical course:
a. That is completely benign
b. Similar to that of b-thalassemia minor
c. Similar to that of a-thalassemia minor (one gene deletion)
d. Similar to that of b-thalassemia major
ANS: B
Hb Lepore is a d-b fusion globin chain with decreased synthesis of the chain. Heterozygotes have a clinical course similar to that of b-thalassemia minor.
Health Professions
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