Which of the following could cause hypercapnic respiratory failure? 1. Smoke inhalation 2. Opiate drug overdose 3. Chronic obstructive pulmonary disease 4. Hypothyroidism
a. 1 and 3 only
b. 1, 2, and 3 only
c. 3 and 4 only
d. 2, 3, and 4 only
ANS: D
This ventilatory drive can be diminished by various factors such as drugs (overdose/sedation), brainstem lesions, diseases of the central nervous system such as multiple sclerosis or Parkinson's disease, hypothyroidism, morbid obesity (e.g., obesity-hypoventilation), and sleep apnea.
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