Diepoxybutane causes chromosomal breakage in which of the following disorders?
a. Acquired aplastic anemia
b. Fanconi anemia
c. Diamond-Blackfan anemia
d. CDA
ANS: B
Diepoxybutane is a deoxyribonucleic acid (DNA) cross-linking agent. When this is added to Fanconi anemia cells in culture, a characteristic chromosomal breakage occurs. This is the diagnostic test for Fanconi anemia.
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A frantic mother called 911 because she found her 18-month-old daughter playing with a bottle of drain cleaner. When assessing this patient, what would provide the strongest evidence that the child ingested some of the liquid?
A) Persistent crying B) Burns to her mouth C) Garbled speech D) Elevated heart rate