Which of the following is the metabolic pathway that generates a net gain of two molecules of ATP for erythrocyte energy needs?
a. EMP
b. 2,3-BPG
c. Methemoglobin reductase reaction
d. Hexose monophosphate pathway
ANS: A
A net gain of two molecules of ATP occurs for every molecule of glucose metabolized via the EMP. When the 2,3-BPG shunt off of the EMP pathway is taken, no net gain of ATP occurs. No energy is generated via the hexose monophosphate pathway. The methemoglobin reductase reaction reduces methemoglobin, the oxidized form of hemoglobin, to its reduced functional form and does not generate energy.
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