When instructing a patient to use a metered-dose inhaler (MDI) without a holding chamber, you should tell the patient:

A) "Place this in your mouth and close your lips around the mouthpiece."
B) "Squeeze the MDI when you exhale."
C) "Open your mouth and place the MDI a few centimeters away."
D) "Inhale as deeply and rapidly as you can when you squeeze the MDI."

C

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