What test is useful for detection of a female carrier of hemophilia A?
a. PTT
b. PT
c. Factor VIII to VWF ratio
d. VWF antigen test
ANS: C
Approximately 90% of female carriers of hemophilia A are detected using the ratio of factor VIII activity to VWF antigen. This is because WVF production is unaffected by factor VIII deficiency, so it should be normal in a female hemophilia A carrier, whereas the factor VIII activity will be less than that of VWF. Thus a discrepancy exists in the concentration of these two proteins.
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