Select the metabolic pathway that converts toxic hydrogen peroxide produced by oxidant drugs to water:

a. Embden-Meyerhof pathway (EMP)
b. 2,3-Biphosphoglycerate (2,3-BPG)
c. Methemoglobin reductase reaction
d. Hexose monophosphate pathway

ANS: D
Hydrogen peroxide is an oxidant and is detoxified via the hexose monophosphate pathway using reduced glutathione. The EMP generates energy in the form of ATP; the 2,3-BPG pathway is a shunt off of the EMP that is important for the reversible binding of oxygen. Methemoglobin reductase is an enzyme that reduces the oxidized form of hemoglobin, called methemoglobin, to its reduced functional form.