Explain the role of epigenetic alterations in cancer development
What will be an ideal response?
Answer: The most common epigenetic change in the development of cancer involves a methylation/demethylation of CpG dinucleotide bases. Cancer can involve demethylation of promoter regions of genes making them transcriptionally ready. Methylation can result in transcriptional silencing of the gene and loss of function of tumor suppressor genes. Deacetylation of key histones can result in gene silencing which may favor growth over differentiation.
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When determining the optimal method to communicate with, assess, treat, and transport a patient with a special health care challenge, the paramedic should:
A) routinely call medical control before talking to a caregiver. B) demonstrate confidence and enlist the expertise of the patient. C) recall that caregivers are often upset and therefore unreliable. D) remain professional and obtain initial information from a caregiver.
________ consent is voluntary written permission by a patient to allow touching, examination, and/or treatment by health care providers.
Fill in the blank(s) with the appropriate word(s).