Which of the following is the metabolic pathway that regulates oxygen delivery to tissues?

a. EMP
b. 2,3-BPG
c. Methemoglobin reductase reaction
d. Hexose monophosphate pathway

ANS: B
2,3-BPG plays a critical role in the effective transport of oxygen to tissue. It is produced via a shunt off of the EMP; elevations in 2,3-BPG are seen in a number of situations such as anemia. Elevated levels result in more effective delivery of oxygen to tissue. None of the other pathways or systems listed play a role in the way oxygen is delivered to tissue.