Compare the differences in the activation of complement that can lead to intravascular hemolysis or extravascular hemolysis

What will be an ideal response?

Answer: In intravascular hemolysis the antibody (usually an IgM) is able to fix complement and cause activation through the MAC. Once C9 has been fixed, the lysis of the cell begins, resulting in intravascular hemolysis. IgG antibodies are not efficient complement fixers, and complement often is fixed only through the C3 component. C3a is released into the plasma and C3b remains on the cell. There are receptors for C3b on splenic and liver macrophages so that cells are removed extravascularly.