Which of the following is least useful in diagnosing and differentiating the thalassemias from each other?
a. Complete blood count (CBC) results
b. Hemoglobin electrophoresis
c. Osmotic fragility
d. Clinical findings
ANS: C
The osmotic fragility is not useful in differentiating the various forms of thalassemia from one another. Hemoglobin electrophoresis is an important tool for differentiating them, whereas CBC results and clinical findings vary depending on the severity of the thalassemic syndrome present and so can be useful.
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