What is the mechanism behind nitric oxide (INOmax)?
a. It dilates pulmonary arterial vascular beds and affects platelet aggregation.
b. It inhibits the degranulation of mast cells.
c. It inhibits the 5-lipoxygenase enzyme that catalyzes the formation of leukotrienes from arachidonic acid.
d. It relaxes vascular smooth muscle by binding to the heme group of cystolic guanylate, activating guanylate cyclase, increasing cyclic GMP.
ANS: D
When inhaled, nitric oxide produces pulmonary vasodilation, reducing pulmonary artery pressure and improving mismatching.
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