Which of the following is necessary for normal platelet aggregation?

a. Ristocetin
b. von Willebrand factor (VWF)
c. Epinephrine
d. Fibrinogen

ANS: D
Normal platelet aggregation requires fibrinogen. Ristocetin is a substance added in vitro that causes platelet to clump. VWF is needed for normal platelet adhesion. Epinephrine is a platelet agonist stimulating platelet aggregation, but it is not necessary.

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