What are the bone marrow findings in hemolytic anemia?
a. Myeloid-to-erythroid (M:E) ratio of 1:1
b. M:E ratio of 5:1
c. Reduced cellularity and increased fat
d. Erythroid hypoplasia
ANS: A
Erythropoiesis is increased (erythroid hyperplasia) in the bone marrow in hemolytic anemia, with no change in the production of granulocytes. The M:E ratio will therefore be decreased (i.e., more erythroid precursors relative to myeloid). Overall cellularity of the bone marrow is increased so that less fat exists.
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