Which of the following statements is true about Hb F?
a. It is the major hemoglobin during fetal life.
b. It is increased in concentration in children up to 2 years old.
c. It is evenly distributed at low concentration in all RBCs of an adult.
d. It has a low oxygen affinity.
ANS: A
Hb F is the major hemoglobin during fetal life and at birth, but its concentration decreases after birth so that by age 6 months it should be less than 1% of the total hemoglobin. It is distributed unevenly in the RBCs of an adult ("F cells"), meaning that it is only found in some RBCs (not in all of them). It has a high oxygen affinity to enable it to extract oxygen from the maternal circulation.
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Answer the following statement true (T) or false (F)