Discuss the concept of genetic risk interacting with stress as demonstrated in the work of Caspi on the 5-HTT gene
Answer:
Caspi's work focused on the 5-HTT transporter gene, which has been studied because several drugs that are used to treat depression have a direct impact on this particular neurotransmitter. There are two alleles or different versions of this gene, one of which is shorter and is associated with reduced efficiency of neural transmission in serotonin pathways. Individuals who inherit this short allele or version of the gene are at particularly high risk for becoming clinically depressed if they experience stressful life events. In the absence of increased stress, the presence of this gene does not increase the person's risk for depression. Both factors seem to be necessary.
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