Identify the lab features of the following disorders:
a. Plasmacytoma
b. Multiple myeloma
c. MGUS
d. Waldenström's macroglobulinemia
What will be an ideal response?
Answer: Plasmacytoma: Localized tumor collection of plasma cells; can lead to multiple myeloma.
Multiple myeloma: Proliferating cell line: plasma cell; immunoglobulin produced: IgG.
MGUS: low level of monoclonal protein produced without the presence of an underlying neoplasm.
Waldenström's macroglobulinemia: Proliferating cell lines: lymphocytes, plasma cells, and lymphoid cells; immunoglobulin produced: IgM.
Neoplasm Features
multiple myeloma
"M" spike in serum or urine
Clonal plasma cells in bone marrow
Related organ or tissue damage (CRAB)
MGUS
M" spike in serum or urine (<30g/L)
Clonal plasma cells in bone marrow <10%
No related organ or tissue damage
Plasmacytoma
Solitary collection of clonal plasma cells
May have "M" spike
No clonal plasma cells elsewhere in bone marrow
No related organ or tissue damage
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