Heme is composed of iron and:
a. Globin chains
b. Oxygen
c. Methemoglobin
d. Protoporphyrin IX
ANS: D
Iron is incorporated into protoporphyrin IX in the mitochondria of a developing red blood cell (RBC) to form heme. Oxygen binds reversibly to the iron in heme provided that iron is in the ferrous (divalent, reduced) state. Globin chains are part of the hemoglobin molecule; four of them exist per molecule, each containing a heme group. Methemoglobin is hemoglobin in which the iron is oxidized to the ferric (trivalent) form; it cannot bind oxygen.
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Fill in the blank(s) with the appropriate word(s).