What chromosome abnormality was the first to be identified and associated with a specific malignancy?

a. Trisomy 8
b. Deletion 7
c. Philadelphia
d. Isocentric chromosome 16

ANS: C
The first chromosome abnormality to be identified and associated with a specific malignancy was the Philadelphia chromosome. It initially was associated with chronic myelogenous leukemia, although clinicians now know it to be found in other hematologic malignancies.