The initial rate of distribution of a drug is heavily dependent on the ________ to various organs.
A) blood flow
B) hepatic portal circulation
C) oxygen distribution
D) reactions
A) blood flow
The initial rate of distribution of a drug is heavily dependent on the blood flow to various organs. Lipid-soluble drugs enter the CNS rapidly. Because of the blood-brain barrier, certain drugs are poorly distributed to the CNS because they pass through the barrier. The three major influencing factors related to drug distribution are: blood flow to the body tissues, how drugs are able to exit the vascular system, and how drugs are able to enter body cells.
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