Assume that you are able to monitor the rate of firing of a single neuron. Assume that you apply a drug that acts as an agonist at the neuron's autoreceptors located on its cell body

Indicate what the most likely effect the drug would have on the neuron's firing rate and provide a reasonable explanation for the mechanism underlying this effect.
What will be an ideal response?

Activation of the autoreceptors would likely hyperpolarize the somatic membrane (e.g., enhancing K+ flow out of the neuron), making the neuron less excitable and decrease its firing rate.