Summarize and explain why patients develop the clinical signs and symptoms oberserved in patients with ALL

What will be an ideal response?

Answer: The excessive proliferation of abnormal blasts that are present causes a "crowding-out effect" of normal hematopoietic cells. This leads to the following: frequent infections (because of low WBCs produced), fatigue, pallor, shortness of breath (from decreased RBCs produced), and bleeding and bruising symptoms (caused by decreased platelets produced).