Which of the following carries blood directly to the liver?
A) A biochemical pathway
B) Renal portal circulation
C) Hepatic portal circulation
D) Lymphatic portal circulation
C) Hepatic portal circulation
The hepatic portal circulation carries blood directly to the liver. If the liver has a high metabolic capacity, the drug is totally inactivated on its first pass, and no therapeutic effects occur. A drug may be given parenterally in order to avoid the first-pass effect. The liver is temporarily bypassed, and the drug reaches therapeutic levels in the systemic blood.
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