Which of the following statements regarding isoimmunization (Rh disease) is correct?

A: Rh disease typically occurs during first-time pregnancies when a woman with Rh-positive blood becomes pregnant by a man with Rh-negative blood.
B: Rh disease is most prominent with subsequent pregnancies and occurs when an Rh-negative mother becomes pregnant by a man with Rh-positive blood.
C: If the mother's blood is Rh positive and her baby's blood is Rh negative, fetal blood can pass into the maternal circulation and produce maternal antibodies to the Rh factor.
D: An Rh-positive woman who becomes pregnant by an Rh-negative man should receive RhoGAM, which prevents her body from attacking subsequent Rh-negative pregnancies.

Answer: B: Rh disease is most prominent with subsequent pregnancies and occurs when an Rh-negative mother becomes pregnant by a man with Rh-positive blood.