Larry has been using heroin for several years. Normally he injects the drug in his basement, but one night on a vacation he injects the drug in his hotel room. Despite the fact that he uses the same heroin and dose that he normally does,

Larry overdoses and dies. What phenomenon is likely responsible?
A) spontaneous recovery
B) preparedness
C) negative punishment
D) conditioned drug tolerance

Answer: D
Rationale: Conditioned drug tolerance develops as the body begins associating environmental cues that accompany drug use with the drug itself. The conditioned responses involve responses that prepare the body for something potentially dangerous. Over time, more of the drug is needed to override these preparatory responses so that the desired effect can be obtained. This can lead to overdoses if this same dose is used without the presence of the environmental cues.