How does tissue inflammation affect local anesthetic drug efficacy?
What will be an ideal response?
When tissues are inflamed at the deposition sites, the lowered pH suppresses the production of base molecules. This suppression may result in insufficient numbers of base molecules (RN) penetrating nerve membranes. Profound anesthesia may become difficult to achieve or, if initially achieved, to sustain. In addition to the increase in hydrogen ions due to the inflammatory response, localized edema and increased circulation may also contribute to failure of profound anesthesia in this situation by decreasing drug concentrations at the delivery site.
You might also like to view...
Your 17-year-old patient is presenting with fatigue, fever, chills, headache, muscle and joint pain. Further history reveals a recent camping trip to the mountains. You note a rash on his back that he had missed. You should suspect:
A) Lyme disease. B) tularemia. C) Rocky Mountain spotted fever. D) rabies.
____________________ refers to sensation of muscle and joint position
Fill in the blank(s) with correct word