The following are preliminary screening test results. Name the suspected disorder associated with each finding, and explain how you would confirm each
a. Positive sugar-water test
b. Positive hemolysis after both incubation periods
c. Normal sTFR levels
d. Many spherocytes noted on PB smear
e. Blasts noted on PB smear
What will be an ideal response?
Answer:
a. Suspected disorder: PNH; confirmation: flow cytometry for an absence of CD55 and CD59
b. Suspected disorder: PCH; confirmation: Donath-Landsteiner test. Further testing is not warranted.
c. Suspected disorder: anemia of chronic disease; confirmation: increased ferritin; low iron and TIBC
d. Suspected disorder: hereditary spherocytosis or hemolysis; confirmation: osmotic fragility
e. Suspected disorder: acute leukemia; confirmation: bone marrow aspirate and cytochemical stains and immunophenotyping
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a. glands and hormones. b. antibodies in the serum. c. bacteria and fungi. d. tumors or cancer.
The skin disorder that commonly appears as facial redness, predominantly over the cheeks and nose, is ________ and results from dilation of small facial blood vessels.
Fill in the blank(s) with the appropriate word(s).